|Accelerator Chemical Name|
Initial M.P. (Min) ≥ °C
Loss on drying (Max) ≤ %
Ash (Max) ≤ %
Residues on 150μm sieve, % ≤
Oil content, %
Granular diameter mm
Abbreviated as BPG or DPG in English, it is an important allosteric effector of hemoglobin.
The binding of 2,3-DPG in red blood cells to deoxyhemoglobin stabilizes the spatial conformation of deoxyhemoglobin, thereby reducing the affinity of hemoglobin for O2 and promoting the dissociation of O2 and hemoglobin. Especially when blood passes through the tissue, the presence of 2,3-DPG in the red blood cells can significantly increase the release of O2 for tissue needs. In addition, patients with severe obstructive emphysema with pulmonary ventilation disorder and normal people can adjust tissue by changing the concentration of 2,3-DPG in red blood cells when rising from sea level to high altitude or high altitude in a short time. Get the amount of O2.
In the presence of BPG, the oxygenation of hemoglobin can be expressed by the following equation:
HbBPG + 4O2 → Hb(O2)4 + BPG (Note: This is a reversible reaction)
The 2,3-diphosphoglycerate branch The important role of 2,3-diphosphoglycerate (2,3-DPG) in red blood cells is to regulate the O2 function of hemoglobin.
The difference between mature red blood cell glycolysis and other cells is the production of 2,3-DPG. The content of 2,3-DPG was the highest in the glycolysis intermediate (in the arteriovenous blood: the content of 2,3-DPG was 177 times and 239 times that of 3-phosphoglycerate). This is because of the presence of diphosphoglycerate (DPG) mutase and 2,3-DPG phosphatase in red blood cells. The reactions catalyzed by these two enzymes are irreversible. Under normal circumstances, the negative feedback effect of 2,3-diphosphoglycerate on DPG mutase is greater than the inhibition of 3-phosphoglycerate, so glucose in red blood cells is still mainly glycolysis to produce lactic acid. Due to the low activity of 2,3-DPG phosphatase, 2,3-DPG production is greater than decomposition, resulting in higher levels of 2,3-DPG in red blood cells.